Web27 de fev. de 2011 · Modulation of Hif-2α predominates over hepcidin in the regulation of intestinal iron ... (2007) ROS mediate the hypoxic repression of the hepcidin gene by inhibiting C/EBPalpha and STAT-3. Biochem Biophys Res ... Simon MC, Vaulont S, Peyssonnaux C (2009) HIF-2alpha, but not HIF-1alpha, promotes iron absorption in … Web3 de out. de 2013 · HIF-2alpha regulates Oct-4: effects of hypoxia on stem cell function, embryonic development, and tumor growth. Genes Dev. 2006; 20: 557-570. Crossref; ... Taken together, these data suggest that HIF-2α KD increases ROS production and affects mitochondria homeostasis (Figure 5D).
The role of hypoxia-inducible factor-2 in digestive system cancers
Web22 de jan. de 2024 · Radiation therapy causes damage to cancer cells via production of reactive oxygen species (ROS) which damages the cell DNA. ... Yuan JQ, Yuan K. HIF … Web30 de mai. de 2013 · The mechanism underlying upregulation of HIF-2α might be multifold. ROS could be an additional factor that induces expression of HIF and activate protective ... Morris MA, Oktay Y, Bennett M, Garcia JA (2003) The HIF family member EPAS1/HIF-2alpha is required for normal hematopoiesis in mice. Blood 102: 1634–1640. ... small pool filter pumps
Frontiers Non-Canonical Mechanisms Regulating Hypoxia …
Web6 de jun. de 2015 · HIF-1alpha+/- mice manifest blunted rises in right ventricular pressure and right ventricular hypertrophy in response to chronic hypoxia (10% oxygen for 3 weeks), 61 whereas in a different study HIF-2alpha+/- mice exposed to a similar stress (10% oxygen for 4 weeks) manifest essentially total loss of the pulmonary hypertensive response. 62 … Web21 de mar. de 2024 · GeneCards Summary for HIF1A Gene. HIF1A (Hypoxia Inducible Factor 1 Subunit Alpha) is a Protein Coding gene. Diseases associated with HIF1A include Retinal Ischemia and Enchondromatosis, Multiple, Ollier Type . Among its related pathways are Signaling by PTK6 and Regulation of activated PAK-2p34 by proteasome mediated … Web4 de abr. de 2024 · Mouse models of liver HIF overexpression demonstrated that both HIF-1alpha and HIF-2alpha contribute to hepcidin repression in vivo. Deficiency of HIF-1alpha or HIF-1beta in Tie2-lineage cells resulted in delayed wound closure, reduced vascularization, decreased cutaneous blood flow, impaired bone marrow-derived angiogenic cell … highlights ierland